Tripeptide-29

INCI: Tripeptide-29
Category: Signal Peptide / Collagen-Stimulating Active
Used in: Serums, anti-ageing moisturisers, body firming treatments
Typical Usage Level (Topical): 0.1-5%

What This Ingredient Does

Tripeptide-29 is composed of glycine-proline-hydroxyproline the same amino acid sequence that forms the repeating unit of the collagen triple helix. When applied topically, it functions as a collagen-mimicking signal: fibroblasts recognise the sequence as a building block and respond by increasing collagen synthesis. Unlike some peptides that mimic degradation fragments to trigger a repair response, Tripeptide-29 acts more directly as a structural precursor signal, making it particularly targeted at rebuilding the skin's collagen matrix rather than broadly stimulating repair.

Key Benefits

• Directly mimics collagen's amino acid sequence to signal fibroblasts to produce more collagen

• Supports rebuilding of the skin's structural matrix in areas of thinning or volume loss

• Improves skin firmness and reduces fine line appearance with consistent use

• Targeted mechanism makes it a clean, single-function collagen-support ingredient

• Well-tolerated across skin types

Who It's Best For

• Those with visibly thinning skin, loss of facial volume, or weakened skin structure

• Adults 35+ looking for targeted collagen matrix support

• Can be layered with Palmitoyl Tripeptide-1 or Tetrapeptide-21 for a multi-peptide collagen approach

• Suitable for sensitive skin

Clinical Note by Dr. Su

The mechanism behind Tripeptide-29 is straightforward and biologically sound — you are giving the skin a fragment of what collagen is made of, and the skin responds by making more. It is not a complex ingredient, but its simplicity is a strength. Results are gradual and cumulative; track changes over 10–12 weeks.