Tranexamic Acid

INCI: Tranexamic Acid
Category: Skin brightening active, anti-pigmentation agent
Used in: Skincare
Typical Usage Level (Topical):
2% – 5% in leave-on formulations (serums, lotions, creams)
Concentrations within this range are most commonly evaluated in clinical studies for pigmentation concerns.

What This Ingredient Does

Tranexamic acid is a synthetic molecule originally used in medicine for its anti-fibrinolytic properties. In dermatology, it has gained attention for its ability to improve hyperpigmentation, particularly melasma and post-inflammatory hyperpigmentation.

Topically, tranexamic acid works by interfering with the interaction between keratinocytes and melanocytes. It helps reduce the activation of melanocytes triggered by inflammation, UV exposure, and vascular factors, all of which contribute to uneven pigmentation.

Unlike exfoliating acids that work by removing pigmented skin cells, tranexamic acid targets pigmentation at a signaling level. This makes it especially useful for individuals who cannot tolerate frequent exfoliation or stronger pigment-correcting actives.

Benefits

• Helps reduce the appearance of melasma and dark patches

• Supports more even skin tone over time

• Calms inflammation linked to post-acne pigmentation

• Suitable for sensitive and barrier-compromised skin

• Can be used alongside other brightening ingredients

Who It’s Suitable For

• Melasma-prone skin

• Post-inflammatory hyperpigmentation (PIH)

• Uneven skin tone due to acne or sun exposure

• Sensitive skin that reacts poorly to exfoliating acids

Note by Dr. Su

(M.D. Dermatologist)
Tranexamic acid is a well-studied option for managing pigmentation concerns, especially melasma. It works best with consistent use and strict sun protection rather than as a quick-fix brightening agent.

References

• Journal of the American Academy of Dermatology, 2016 – Studies on tranexamic acid in melasma

• Journal of Dermatological Treatment, 2014 – Topical tranexamic acid for hyperpigmentation

• Clinical, Cosmetic and Investigational Dermatology, 2019 – Review of tranexamic acid in pigmentary disorders