SYN-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate)

INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate
 Trade Name: SYN-AKE
Category: Synthetic Neuropeptide / Expression Line Active
Used in: Serums, eye creams, expression-line treatments, premium moisturisers
Typical Usage Level (Topical): 0.5–4%

What This Ingredient Does

SYN-AKE is a synthetic tripeptide designed to mimic waglerin-1, a compound found in the venom of the Temple Viper (Tropidolaemus wagleri). Waglerin-1 blocks nicotinic acetylcholine receptors at the neuromuscular junction, preventing the nerve signal from completing the muscle contraction. SYN-AKE replicates this mechanism topically and reversibly it competes with acetylcholine at the receptor site, reducing the strength and frequency of muscle contractions that cause expression lines. The effect is temporary and localised; there is no systemic absorption or paralytic risk at cosmetic concentrations.

Works synergistically with Leuphasyl and Acetyl Hexapeptide-8 (Argireline) for a multi-pathway neuropeptide approach to expression line reduction.

Key Benefits

  • Temporarily reduces muscle contraction intensity at expression-prone areas

  • Targets nicotinic acetylcholine receptors — a different mechanism from Argireline (SNARE) and Leuphasyl (enkephalin)

  • Smooths the appearance of forehead lines, crow's feet, and glabellar lines

  • Reversible and localised — no systemic effect at cosmetic use levels

  • Adds a third complementary neuropeptide pathway when combined with Argireline and Leuphasyl

Who It's Best For

  • Those with moderate to established expression lines who want a topical neuropeptide approach

  • Users already in a neuropeptide routine (Argireline + Leuphasyl) looking to add a third mechanism

  • Those interested in non-invasive alternatives to injectable treatments for muscle-driven lines

  • Not a clinical replacement for botulinum toxin; most appropriate for prevention and maintenance

Clinical Note by Dr. Su

SYN-AKE is one of the more mechanistically credible topical neuropeptides — the receptor target is the same as venom-derived compounds, just replicated synthetically and at safe cosmetic concentrations. It will not produce the same magnitude of result as a medical injectable, but for those who want a science-backed topical option for expression lines, it is among the strongest available. Combine with Argireline and Leuphasyl for best effect.

References

  • Dragomirescu AO, et al. (2011). Clinical evaluation of a new synergistic formulation of two snake venom derived peptides. Journal of Cosmetics, Dermatological Sciences and Applications. (SYN-AKE mechanism reference)

  • Blanes-Mira C, et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science. PMID: 18498523 (neuropeptide mechanism context)

(These references explain the scientific context not proprietary product testing.)