Glutathione (Topical)

Category: Antioxidant
Used in: Skincare (serums, creams)

INCI & Usage Level

INCI:
Glutathione

Typical Usage Level:
0.5% – 2% in leave-on skincare formulations

Glutathione at a Glance

• Naturally present in skin cells
  
• Tripeptide composed of cysteine, glutamic acid, and glycine
  
• Protects against environmental and oxidative stress
  
• Supports brighter-looking and more even-toned skin
  

What This Ingredient Does

Topical glutathione is a naturally occurring antioxidant used in skincare to help neutralize free radicals generated by UV exposure, pollution, and daily environmental stressors.

In cosmetic formulations, glutathione supports a more even-looking complexion by influencing pathways involved in excess pigment formation and oxidative damage. It also helps enhance and stabilize other antioxidants commonly used in skincare, such as vitamin C, improving overall formulation performance.

With consistent use, topical glutathione contributes to brighter, healthier-looking skin and improved skin radiance.

To understand how glutathione functions as the skin’s master antioxidant and how it supports radiance at a cellular level, explore our detailed Derm School article on glutathione and radiant skin

Benefits

• Helps brighten dull-looking skin
  
• Supports even skin tone appearance
  
• Protects against oxidative damage
  
• Enhances antioxidant performance in formulations
  

Who It’s Suitable For

• Dull or uneven skin tone
  
• Skin exposed to pollution or UV stress
  
• Early signs of aging
  
• Most skin types when well formulated
  

How It’s Commonly Used

Topical glutathione is commonly found in serums and antioxidant treatments, often paired with vitamin C, niacinamide, or other barrier-supporting ingredients for enhanced skin benefits.

Note by Dr. Su

(M.D. Dermatologist)

Topical glutathione works best as part of a daily antioxidant routine combined with sunscreen and barrier care. With consistent use, it supports brighter, healthier-looking skin.

References

Journal of Cosmetic Dermatology, June 2019, pages 728–737
Clinical, Cosmetic and Investigational Dermatology, April 2017, pages 147–153
Journal of Dermatologic Science, May 2010, pages 85–90