Glutathione (Oral)

Category: Antioxidant
Used in: Supplements

INCI & Usage Level

INCI: L - Glutathione

Typical Daily Dosage: 500 mg per day, as used in clinically aligned oral beauty formulations

Glutathione at a Glance

• Naturally produced in the body
  
• Central to antioxidant pathways
  
• Supports skin glow and overall cellular health
  
• Liposomal delivery improves absorption and stability
  

What This Ingredient Does

Oral glutathione plays a key role in maintaining the body’s internal antioxidant defenses. It helps counter oxidative stress that can impact skin clarity, tone, and overall skin health.

Liposomal glutathione is encapsulated within phospholipid structures, which protect the molecule from breakdown in the digestive system and improve absorption. This delivery format allows glutathione to remain more bioavailable compared to conventional forms.

At adequate daily dosages, oral glutathione supports an inside-out approach to skin health by reducing systemic oxidative stress and supporting clearer, more radiant-looking skin over time.

To understand how glutathione functions as the skin’s master antioxidant and how it supports radiance at a cellular level, explore our detailed Derm School article on glutathione and radiant skin.

Benefits

• Boosts skin glow
  
• Helps reduce oxidative stress
  
• Fades pigmentation and supports radiance from within
  
• Complements topical skincare routines
  

Who It’s Suitable For

• Skin exposed to high environmental stress
  
• Dull or tired-looking skin
  
• Hyperpigmented or uneven skin tone
  
• Individuals following an inside-out skin health approach
  

How It’s Commonly Used

Oral glutathione is taken daily as a supplement, often in liposomal form for improved absorption. It is commonly paired with vitamin C to support antioxidant recycling and stability.

Note by Dr. Su

(M.D. Dermatologist)

For oral glutathione, dosage and delivery matter. Liposomal glutathione at clinically aligned doses, such as 500 mg daily, supports optimal absorption and makes it a valuable part of an inside-out skin health routine.

References

Clinical, Cosmetic and Investigational Dermatology, October 2014, pages 267–274
Nutrients, August 2017, pages 1–27
Dermato-Endocrinology, July 2012, pages 308–319
Free Radical Biology and Medicine, October 1994, pages 333–349